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Uncoupling proteins--a new family of proteins with unknown function.

In English

Författare

Summary, in English

Uncoupling proteins are inner mitochondrial membrane proteins, which dissipate the proton gradient, releasing the stored energy as heat. Five proteins have been cloned, named UCP1, UCP2, UCP3, UCP4 and UCP5/BMCP1. These proteins are structurally related but differ in tissue expression. UCP1 is expressed uniquely in the brown adipose tissue, while UCP2 is widely distributed, UCP3 is mainly restricted to skeletal muscle and UCP4 and UCP5/BMCP1 expressed in the brain. The properties and regulation of the uncoupling proteins and their exact function has been the focus of an intense research during recent years. This review briefly summarizes the actual knowledge of the properties and function of this new family of proteins. While UCP1 has a clear role in energy homeostasis, the newcomers UCP2-UCP5 may have more delicate physiological importance acting as free radical oxygen scavengers and in the regulation of ATP-dependent processes, such as secretion.

Avdelning/ar

Publiceringsår

2002

Språk

Engelska

Sidor

1-11

Publikation/Tidskrift/Serie

Nutritional Neuroscience

Volym

5

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Taylor & Francis

Ämne

  • Basic Medicine

Nyckelord

  • Free Oxygen Radical
  • Thermogenesis
  • Energy
  • Mitochondria
  • Obesity
  • Atp

Status

Published

Forskningsgrupp

  • Appetite Regulation

ISBN/ISSN/Övrigt

  • ISSN: 1476-8305