IL-22 affects smooth muscle cell phenotype and plaque formation in apolipoprotein E knockout mice.

Summary, in English

IL-22 is a recently discovered cytokine that belongs to the family of IL-10 related cytokines. It is produced by activated T-cells and innate lymphoid cells and has been suggested to be involved in tissue repair. As both inflammation and repair play important roles in atherosclerosis we investigated if IL-22 deficiency influences the disease process in Apoe(-/-) mice.

• Författare: Sara Rattik; Karin Hultman; Uwe Rauch; Ingrid Söderberg; Lena Sundius; Irena Ljungcrantz; Anna Hultgårdh; Maria Wigren; Harry Björkbacka; Gunilla Nordin Fredrikson; Jan Nilsson
• Avdelning/ar: Kardiovaskulär forskning - immunitet och ateroskleros; Kärlväggsbiologi; EXODIAB: Excellence of Diabetes Research in Sweden; EpiHealth: Epidemiology for Health
• Publiceringsår: 2015
• Språk: Engelska
• Sidor: 506-514
• Publikation/Tidskrift/Serie: Atherosclerosis
• Volym: 242
• Issue: 2
• Fulltext: - 31 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/26298743?dopt=Abstract; http://dx.doi.org/10.1016/j.atherosclerosis.2015.08.006
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Cardiac and Cardiovascular Systems
• Status: Published
• Forskningsgrupp: Cardiovascular Research - Immunity and Atherosclerosis; Vessel Wall Biology
• ISBN/ISSN/Övrigt: ISSN: 1879-1484