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Antral G-cell in gastrin and gastrin-cholecystokinin knockout animals

In English

Författare

Summary, in English

The antral hormone gastrin is the key regulator of gastric acid secretion, mucosal growth and differentiation. Gastrin is synthesized in the endocrine G-cells in the antroduodenal mucosa. We have now examined the way in which the loss of gastrin alone or gastrin plus cholecystokinin (CCK) affects the antral G-cell. Immunohistochemistry, radioimmunoassay and quantitative real-time polymerase chain reaction techniques were employed to examine the expression of genes belonging to the G-cell secretory pathway in gastrin and gastrin-CCK knockout mice. Transmission electron microscopy was used to examine the ultrastructure of the G-cells. The number of G-cells increased but the secretory granules were few and abnormally small in the G-cells of both mouse models compared with wildtypes. Thus, gastrin is not necessary for the formation of G-cells as such but the lack of gastrin reduces the number and size of their secretory granules suggesting that gastrin is vital for the formation and/or maintenance of secretory granules in G-cells.

Publiceringsår

2005

Språk

Engelska

Sidor

141-146

Publikation/Tidskrift/Serie

Cell and Tissue Research

Volym

321

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Cell Biology

Nyckelord

  • transgenic mice
  • ultrastructure
  • G-cells
  • secretion
  • gastrin
  • cholecystokinin

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1432-0878