Författare
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Andrew P. Morris
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Benjamin F. Voight
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Tanya M. Teslovich
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Teresa Ferreira
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Ayellet V. Segre
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Valgerdur Steinthorsdottir
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Rona J. Strawbridge
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Hassan Khan
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Harald Grallert
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Anubha Mahajan
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Inga Prokopenko
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Hyun Min Kang
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Christian Dina
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Tonu Esko
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Ross M. Fraser
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Stavroula Kanoni
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Ashish Kumar
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Vasiliki Lagou
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Claudia Langenberg
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Jian'an Luan
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Cecilia M. Lindgren
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Martina Mueller-Nurasyid
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Sonali Pechlivanis
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N. William Rayner
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Laura J. Scott
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Steven Wiltshire
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Loic Yengo
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Leena Kinnunen
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Elizabeth J. Rossin
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Soumya Raychaudhuri
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Andrew D. Johnson
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Antigone S. Dimas
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Ruth J. F. Loos
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Sailaja Vedantam
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Han Chen
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Jose C. Florez
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Caroline Fox
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Ching-Ti Liu
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Denis Rybin
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David J. Couper
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Wen Hong L. Kao
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Man Li
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Marilyn C. Cornelis
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Peter Kraft
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Qi Sun
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Rob M. van Dam
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Heather M. Stringham
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Peter S. Chines
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Krista Fischer
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Pierre Fontanillas
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Oddgeir L. Holmen
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Sarah E. Hunt
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Anne U. Jackson
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Augustine Kong
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Robert Lawrence
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Julia Meyer
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John R. B. Perry
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Carl G. P. Platou
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Simon Potter
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Emil Rehnberg
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Neil Robertson
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Suthesh Sivapalaratnam
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Alena Stancakova
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Kathleen Stirrups
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Gudmar Thorleifsson
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Emmi Tikkanen
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Andrew R. Wood
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Peter Almgren
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Mustafa Atalay
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Rafn Benediktsson
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Lori L. Bonnycastle
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Noel Burtt
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Jason Carey
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Guillaume Charpentier
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Andrew T. Crenshaw
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Alex S. F. Doney
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Mozhgan Dorkhan
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Sarah Edkins
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Valur Emilsson
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Elodie Eury
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Tom Forsen
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Karl Gertow
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Bruna Gigante
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George B. Grant
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Christopher J. Groves
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Candace Guiducci
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Christian Herder
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Astradur B. Hreidarsson
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Jennie Hui
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Alan James
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Anna Jonsson
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Wolfgang Rathmann
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Norman Klopp
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Jasmina Kravic
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Kaarel Krjutskov
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Cordelia Langford
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Karin Leander
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Eero Lindholm
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Stephane Lobbens
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Satu Mannisto
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Ghazala Mirza
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Thomas W. Muehleisen
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Bill Musk
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Melissa Parkin
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Loukianos Rallidis
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Jouko Saramies
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Bengt Sennblad
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Sonia Shah
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Gunnar Sigurdsson
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Angela Silveira
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Gerald Steinbach
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Barbara Thorand
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Joseph Trakalo
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Fabrizio Veglia
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Roman Wennauer
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Wendy Winckler
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Delilah Zabaneh
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Harry Campbell
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Cornelia van Duijn
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Andre G. Uitterlinden
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Albert Hofman
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Eric Sijbrands
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Goncalo R. Abecasis
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Katharine R. Owen
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Eleftheria Zeggini
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Mieke D. Trip
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Nita G. Forouhi
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Ann-Christine Syvanen
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Johan G. Eriksson
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Leena Peltonen
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Markus M. Noethen
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Beverley Balkau
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Colin N. A. Palmer
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Valeriya Lyssenko
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Tiinamaija Tuomi
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Bo Isomaa
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David J. Hunter
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Lu Qi
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Alan R. Shuldiner
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Michael Roden
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Ines Barroso
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Tom Wilsgaard
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John Beilby
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Kees Hovingh
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Jackie F. Price
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James F. Wilson
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Rainer Rauramaa
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Timo A. Lakka
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Lars Lind
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George Dedoussis
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Inger Njolstad
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Nancy L. Pedersen
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Kay-Tee Khaw
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Nicholas J. Wareham
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Sirkka M. Keinanen-Kiukaanniemi
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Timo E. Saaristo
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Eeva Korpi-Hyovalti
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Juha Saltevo
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Markku Laakso
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Johanna Kuusisto
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Andres Metspalu
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Francis S. Collins
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Karen L. Mohlke
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Richard N. Bergman
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Jaakko Tuomilehto
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Bernhard O. Boehm
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Christian Gieger
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Kristian Hveem
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Stephane Cauchi
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Philippe Froguel
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Damiano Baldassarre
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Elena Tremoli
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Steve E. Humphries
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Danish Saleheen
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John Danesh
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Erik Ingelsson
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Samuli Ripatti
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Veikko Salomaa
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Raimund Erbel
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Karl-Heinz Joeckel
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Susanne Moebus
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Annette Peters
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Thomas Illig
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Ulf de Faire
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Anders Hamsten
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Andrew D. Morris
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Peter J. Donnelly
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Timothy M. Frayling
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Andrew T. Hattersley
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Eric Boerwinkle
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Olle Melander
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Sekar Kathiresan
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Peter Nilsson
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Panos Deloukas
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Unnur Thorsteinsdottir
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Leif Groop
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Kari Stefansson
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Frank Hu
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James S. Pankow
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Josee Dupuis
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James B. Meigs
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David Altshuler
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Michael Boehnke
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Mark I. McCarthy
Summary, in English
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genomewide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.
