From the bone marrow to the thymus: the road map of early stages of T-cell development.
Publikation/Tidskrift/Serie: Critical Reviews in Immunology
Dokumenttyp: Artikel i tidskrift
Förlag: Begell House
The thymus produces new T cells throughout life but has no self-renewing ability and requires replenishment and recruitment of progenitors derived from the bone marrow. Despite the progress in delineation of mature blood cell development several questions remain regarding T lymphopoiesis. Understanding the developmental stages from multipotent hematopoietic stem cells (HSCs) to the T-cell lineage-restricted progenitors has many potential clinical implications as it is important for understanding malignant transformation in T-cell cancer, accelerating T-cell regeneration after bone marrow transplantation and chemotherapy, and establishing new therapies to treat T-cell immune deficiencies. This review focuses on the steps leading from the HSCs in the bone marrow to the lineage committed T cells inside the thymus.
- Cell and Molecular Biology
- T-Lymphocytes: immunology
- Thymus Gland: cytology
- Thymus Gland: immunology
- Bone Marrow: immunology
- T-Lymphocytes: cytology
- Lymphoid Development and Regulation
- ISSN: 1040-8401