Growth and development of human muscle: a quantitative morphological study of whole vastus lateralis from childhood to adult age
Författare
Summary, in English
The mechanisms underlying the increase in volume of muscle tissue, and the functional development of muscle fibers from childhood through adolescence to adult age, have been studied. Cross sections of autopsied whole vastus lateralis muscle from 22 previously physically healthy males, 5 to 37 years of age, were prepared enzyme histochemically (myofibrillar ATPase) and examined morphometrically. The data obtained on muscle cross-sectional area, size, total number, and proportion of type 1 (slow-twitch) and type 2 (fast-twitch) fibers were analyzed using linear regression techniques. The results show that the increase in muscle cross-sectional area from childhood to adult age is caused by an increase in mean fiber size. This is accompanied by a functional development of the fiber population: the proportion of type 2 fibers increases significantly from the age of 5 (approx. 35%) to the age of 20 (approx. 50%), which, in the absence of any discernible effect on the total number of fibers, is most likely caused by a transformation of type 1 to type 2 fibers.
Publiceringsår
1992
Språk
Engelska
Sidor
404-409
Publikation/Tidskrift/Serie
Muscle and Nerve
Volym
15
Issue
3
Dokumenttyp
Artikel i tidskrift
Förlag
John Wiley & Sons Inc.
Ämne
- Neurology
- Surgery
Nyckelord
- aging
- histocytochemistry
- growth
- muscles
- physiological adaptation
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0148-639X