Blood group specific oligosaccharides from faeces of a blood group A breast-fed infant

Summary, in English

Four different oligosaccharides were isolated from faeces collected from a blood group A, secretor, breast-fed infant. Three of these, GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-4Glc (A-tetrasaccharide), GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-4[Fuc alpha 1-3]Glc (A-pentasaccharide) and 1-3[Fuc alpha 1-4]GlcNAc beta 1-3Gal beta 1-4Glc (A-heptasaccharide) have previously found in urine, whereas GalNAc alpha 1-3[Fuc alpha 1-2]Gal beta 1-3GlcNAc beta 1-3Gal beta 1-4Glc (A-hexasaccharide) is a new compound. Structures were deduced by mass spectrometry of permethylated and N-trifluoroacetylated oligosaccharide alditols. The latter gave more structural information than the corresponding N-acetyl derivatives. The four oligosaccharides were tested for blood group A activity and all were found to inhibit the binding of anti-A antibody to blood group A substance.

• Författare: H Sabharwal; B Nilsson; Alan Chester; Sture Sjöblad; A Lundblad
• Avdelning/ar: Avdelningen för hematologi och transfusionsmedicin; Pediatrik, Lund
• Publiceringsår: 1984
• Språk: Engelska
• Sidor: 1105-1112
• Publikation/Tidskrift/Serie: Molecular Immunology
• Volym: 21
• Issue: 11
• Länkar: http://dx.doi.org/10.1016/0161-5890(84)90121-4
• Dokumenttyp: Artikel i tidskrift
• Förlag: Pergamon Press Ltd.
• Ämne: Immunology in the medical area
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1872-9142