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Binding of Haemophilus influenzae to purified mucins from the human respiratory tract

In English

Författare

Summary, in English

Mucins are high-molecular-weight glycoproteins and major constituents of the mucus layer which covers the airway surface. We have studied the interactions between bacteria, mucins, and epithelial cells from the human respiratory tract. Nontypeable strains of Haemophilus influenzae were found to bind to purified airway mucins in suspension and on solid phase. Mucins in suspension inhibited the attachment of these strains to nasopharyngeal epithelial cells, while mucin coating of the cells enhanced their binding. In contrast, strains of Streptococcus pneumoniae and encapsulated and other nontypeable H. influenzae strains failed to interact with mucins. These H. influenzae strains used other strategies for adherence to epithelial cells. The type b strain 770235 attached via fimbriae but also expressed a subcapsular adhesin that was detected in a capsule- and fimbria-defective mutant. Mucin pretreatment of these bacteria did not inhibit adherence, but mucin pretreatment of epithelial cells inhibited adherence, probably by shielding of the receptors for these adhesins. Non-mucin-binding nontypeable and encapsulated H. influenzae strains would, therefore, adhere only after disruption of the mucus layer and exposure of cellular receptors. Differences in tissue toxicity and invasiveness among H. influenzae strains may also be influenced by the mucin interactions of the strains.

Publiceringsår

1995-07

Språk

Engelska

Sidor

92-2485

Publikation/Tidskrift/Serie

Infection and Immunity

Volym

63

Issue

7

Dokumenttyp

Artikel i tidskrift

Förlag

American Society for Microbiology

Ämne

  • Microbiology in the medical area

Nyckelord

  • Bacterial Adhesion
  • Epithelium
  • Fimbriae, Bacterial
  • Haemophilus influenzae
  • Humans
  • Mucins
  • Nasopharynx
  • Respiratory System
  • Streptococcus pneumoniae

Status

Published

Forskningsgrupp

  • Diabetic Complications
  • Experimental Infection Medicine, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 0019-9567