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Reverse pharmacology and the de-orphanization of 7TM receptors

In English

Författare

Summary, in English

Approximately 800 genes coding for seven-transmembrane, G-protein-coupled receptors have so far been recognized. In spite of this, many of these receptors are defined by their sequence only, and are therefore classified as orphan receptors. Without knowing what their endogenous ligands are, we lack the information needed to understand their physiological role and hence cannot make use of them as drug targets. In this communication, we discuss different strategies, as well as difficulties in the deorphanizing process.

Avdelning/ar

  • Immunology

Publiceringsår

2004

Språk

Engelska

Sidor

99-104

Publikation/Tidskrift/Serie

Drug Discovery Today: Technologies

Volym

2

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Immunology in the medical area

Status

Published

Forskningsgrupp

  • Immunology

ISBN/ISSN/Övrigt

  • ISSN: 1740-6749