Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.
Författare
Summary, in English
The Gq-coupled 5-hydroxytryptamine 2B (5-HT2B) receptor is known to regulate the proliferation of islet beta cells during pregnancy. However, the role of serotonin in the control of insulin release is still controversial. The aim of the present study was to explore the role of the 5-HT2B receptor in the regulation of insulin secretion in mouse and human islets, as well as in clonal INS-1(832/13) cells.
Avdelning/ar
Publiceringsår
2016-01-06
Språk
Engelska
Sidor
744-754
Publikation/Tidskrift/Serie
Diabetologia
Volym
59
Issue
4
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Springer
Ämne
- Endocrinology and Diabetes
Status
Published
Forskningsgrupp
- Celiac Disease and Diabetes Unit
- Diabetes - Islet Cell Exocytosis
- Diabetes - Molecular Metabolism
- Genomics, Diabetes and Endocrinology
- Neuroendocrine Cell Biology
ISBN/ISSN/Övrigt
- ISSN: 1432-0428