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Animal deoxyribonucleoside kinases: forward and retrograde evolution of their substrate specificity

Författare:
  • Jure Piskur
  • Michael Sandrini
  • W. Knecht
  • Birgitte Munch-Petersen
Publiceringsår: 2004
Språk: Engelska
Sidor: 41339-41339
Publikation/Tidskrift/Serie: FEBS Letters
Volym: 560
Nummer: 1-3
Dokumenttyp: Artikel i tidskrift
Förlag: Wiley-Blackwell

Sammanfattning

Abstract

Deoxyribonucleoside kinases, which catalyse the phosphorylation of deoxyribonucleosides, are present in several copies in most multicellular organisms and therefore represent an excellent model to study gene duplication and specialisation of the duplicated copies through partitioning of substrate specificity. Recent studies suggest that in the animal lineage one of the progenitor kinases, the so-called dCK/dGK/TK2-like gene, was duplicated prior to separation of the insect and mammalian lineages. Thereafter, insects lost all but one kinase, dNK (EC 2.7.1.145), which subsequently, through remodelling of a limited number of amino acid residues, gained a broad substrate specificity.

Nyckelord

  • Biological Sciences
  • nucleic acid precursors
  • evolution
  • enzyme
  • kinases

Övriga

Published
  • ISSN: 1873-3468

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