Assessment of inactive, active and mixed atherosclerotic plaques by 18F-FDG-PET; an age group-based correlation with cardiovascular risk factors

Summary, in English

PURPOSE: The aim of this study was to assess the atherosclerotic plaques in a large asymptomatic population stratified based on age and sex.

METHODS: [18F]-2-fluoro-2-deoxy-D-glucose (FDG)-PET/CT of 100 men and 100 women, divided in four age groups were examined to assess FDG-accumulating active, calcified inactive and mixed atherosclerotic plaques in eight defined vessel segments.

RESULTS: There was a high correlation between the total number of cardiovascular risk factors and the number of FDG-accumulating active plaques as well as the number of calcified inactive plaques. There was a significant difference in the number of plaques between all age-groups except for active plaques in age groups 60-70 and 80-90 years.

CONCLUSIONS: There is a correlation between the number of cardiovascular risk factors and the number of FDG-accumulating atherosclerotic lesions in this patient material. Statin-treatment was associated with significantly lower numbers of active plaques.

• Författare: Johan Wassélius; Stig Larsson; Anders Sundin; Hans Jacobsson
• Publiceringsår: 2009-02
• Språk: Engelska
• Sidor: 40-133
• Publikation/Tidskrift/Serie: International Journal of Cardiovascular Imaging
• Volym: 25
• Issue: 2
• Länkar: http://dx.doi.org/10.1007/s10554-008-9366-5
• Dokumenttyp: Artikel i tidskrift
• Förlag: Springer
• Ämne: Cardiac and Cardiovascular Systems
• Nyckelord: Adult; Age Factors; Aged; Aged, 80 and over; Atherosclerosis; Cardiovascular Diseases; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiographic Image Interpretation, Computer-Assisted; Radiopharmaceuticals; Risk Factors; Tomography, X-Ray Computed; Journal Article; Research Support, Non-U.S. Gov't
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1875-8312