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From PDE3B to the regulation of energy homeostasis.

In English

Författare

  • Eva Degerman
  • Faiyaz Ahmad
  • Youn Wook Chung
  • Emilia Guirguis
  • Bilal Omar
  • Lena Stenson
  • Vincent Manganiello

Summary, in English

The incidence of obesity in the developed world is increasing at an alarming rate. Concurrent with the increase in the incidence of obesity is an increase in the incidence of type 2 diabetes. Cyclic AMP (cAMP) and cGMP are key second messengers in all cells; for example, when it comes to processes of relevance for the regulation of energy metabolism, cAMP is a key mediator in the regulation of lipolysis, glycogenolysis, gluconeogenesis and pancreatic β cell insulin secretion. PDE3B, one of several enzymes which hydrolyze cAMP and cGMP, is expressed in cells of importance for the regulation of energy homeostasis, including adipocytes, hepatocytes, hypothalamic cells and β cells. It has been shown, using PDE3 inhibitors and gene targeting approaches in cells and animals, that altered levels of PDE3B result in a number of changes in the regulation of glucose and lipid metabolism and in overall energy homeostasis. This article highlights the complexity involved in the regulation of PDE3B by hormones, and in the regulation of downstream metabolic effects by PDE3B in several interacting tissues.

Publiceringsår

2011

Språk

Engelska

Sidor

676-682

Publikation/Tidskrift/Serie

Current Opinion in Pharmacology

Volym

11

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Endocrinology and Diabetes

Aktiv

Published

Forskningsgrupp

  • Insulin Signal Transduction

ISBN/ISSN/Övrigt

  • ISSN: 1471-4973