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Approximate geodesic distances reveal biologically relevant structures in microarray data

In English

Författare

Summary, in English

Motivation: Genome-wide gene expression measurements, as currently determined by the microarray technology, can be represented mathematically as points in a high-dimensional gene expression space. Genes interact with each other in regulatory networks, restricting the cellular gene expression profiles to a certain manifold, or surface, in gene expression space. To obtain knowledge about this manifold, various dimensionality reduction methods and distance metrics are used. For data points distributed on curved manifolds, a sensible distance measure would be the geodesic distance along the manifold. In this work, we examine whether an approximate geodesic distance measure captures biological similarities better than the traditionally used Euclidean distance. Results: We computed approximate geodesic distances, determined by the Isomap algorithm, for one set of lymphoma and one set of lung cancer microarray samples. Compared with the ordinary Euclidean distance metric, this distance measure produced more instructive, biologically relevant, visualizations when applying multidimensional scaling. This suggests the Isomap algorithm as a promising tool for the interpretation of microarray data. Furthermore, the results demonstrate the benefit and importance of taking nonlinearities in gene expression data into account.

Publiceringsår

2004

Språk

Engelska

Sidor

874-880

Publikation/Tidskrift/Serie

Bioinformatics

Volym

20

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

Oxford University Press

Ämne

  • Bioinformatics and Systems Biology

Nyckelord

  • Lymphoma
  • Microarray
  • Gene expression
  • Manifold learning
  • Lung cancer
  • Isomap
  • Nonlinear dimensionality reduction

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1367-4803