Complement in the immunopathogenesis of rheumatic disease.
Författare
Summary, in English
The complement system has vital protective functions as a humoral component of the innate immune system and also through interactions with the adaptive immune system; however, when inappropriately activated or regulated, complement can cause inflammation and organ damage, and such processes are involved in the pathogenesis of many inflammatory conditions, not least rheumatic diseases. Furthermore, states of complement deficiency can predispose not only to infections, but also to autoimmune disorders, including rheumatic diseases such as systemic lupus erythematosus. In this Review, the mechanisms behind the pathogenic activities of complement in rheumatic diseases are discussed. Potential approaches to therapeutic intervention that focus on regulating complement activities in these disorders are also considered.
Avdelning/ar
Publiceringsår
2012
Språk
Engelska
Sidor
458-468
Publikation/Tidskrift/Serie
Nature Reviews Rheumatology
Volym
8
Issue
8
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Nature Publishing Group
Ämne
- Rheumatology and Autoimmunity
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1759-4804