Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response.

Summary, in English

Yes-associated protein (YAP1) is frequently reported to function as an oncogene in many types of cancer, but in breast cancer results remain controversial. We set out to clarify the role of YAP1 in breast cancer by examining gene and protein expression in subgroups of patient material and by downregulating YAP1 in vitro and studying its role in response to the widely used anti-estrogen tamoxifen.

• Författare: Sophie Lehn; Nicholas P Tobin; Andrew H Sims; Olle Stål; Karin Jirström; Håkan Axelson; Göran Landberg
• Avdelning/ar: Patologi, Malmö; Molekylär patologi, Malmö; Tumörmikromiljö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Avdelningen för translationell cancerforskning
• Publiceringsår: 2014
• Språk: Engelska
• Publikation/Tidskrift/Serie: BMC Cancer
• Volym: 14
• Issue: 1
• Fulltext: - 2 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/24559095?dopt=Abstract; http://dx.doi.org/10.1186/1471-2407-14-119
• Dokumenttyp: Artikel i tidskrift
• Förlag: BioMed Central (BMC)
• Ämne: Cancer and Oncology
• Status: Published
• Forskningsgrupp: Pathology, Malmö; Molecular Pathology, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1471-2407