Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinson's disease.
Författare
Summary, in English
The early clinical trials using fetal ventral mesencephalic (VM) allografts in Parkinson's disease (PD) patients have shown efficacy (albeit not in all cases) and have paved the way for further development of cell replacement therapy strategies in PD. The preclinical work that led to these clinical trials used allografts of fetal VM tissue placed into 6-OHDA lesioned rats, while the patients received similar allografts under cover of immunosuppression in an α-synuclein disease state. Thus developing models that more faithfully replicate the clinical scenario would be a useful tool for the translation of such cell-based therapies to the clinic.
Avdelning/ar
- Wallenberg Neuroscience Centre, Lund
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
Publiceringsår
2015-12-14
Språk
Engelska
Publikation/Tidskrift/Serie
Acta Neuropathologica Communications
Volym
3
Issue
1
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
BioMed Central (BMC)
Ämne
- Neurosciences
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 2051-5960