Synthesis of Imidates : TFA-Mediated Regioselective Amide Alkylation Using Meerwein's Reagent
Författare
Summary, in English
Regioselective O-alkylation of an amide to form the corresponding imidate is a common synthetic problem, often resulting in varying amounts of N-alkylation. Screening existing methods for converting amides to imidates gave inconsistent or irreproducible results, sometimes affording N-alkylamide as the major product. A simple and reliable protocol for amide O-alkylation with complete regioselectivity has been designed, and its scope and efficiency demonstrated on a number of substrates.
Avdelning/ar
Publiceringsår
2016-04-15
Språk
Engelska
Sidor
3470-3472
Publikation/Tidskrift/Serie
Journal of Organic Chemistry
Volym
81
Issue
8
Dokumenttyp
Artikel i tidskrift
Förlag
The American Chemical Society (ACS)
Ämne
- Organic Chemistry
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0022-3263