Reversible Michael additions: Covalent inhibitors and prodrugs.
Författare
Summary, in English
Covalent inhibition is an efficient molecular mechanism for inhibiting enzymes or modulating the function of proteins and is found in the action of many drugs and biologically active natural products. However, it is has been less appreciated that the formation of covalent bonds can be reversible or irreversible. This review focuses on biologically active compounds that are Michael acceptors and how the reversible nature of the Michael addition reaction influences biological activity and how this can be exploited in designing prodrugs.
Avdelning/ar
- Medical Protein Science
Publiceringsår
2012
Språk
Engelska
Sidor
1330-1344
Publikation/Tidskrift/Serie
Mini-Reviews in Medicinal Chemistry
Volym
12
Issue
13
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Bentham Science Publishers
Ämne
- Medicinal Chemistry
Status
Published
Forskningsgrupp
- Medical Protein Science
ISBN/ISSN/Övrigt
- ISSN: 1875-5607