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Animal Models of Parkinson's Disease: Limits and Relevance to Neuroprotection Studies

In English

Författare

  • Erwan Bezard
  • Zhenyu Yue
  • Deniz Kirik
  • Maria Grazia Spillantini

Summary, in English

Over the last two decades, significant strides has been made toward acquiring a better knowledge of both the etiology and pathogenesis of Parkinson's disease (PD). Experimental models are of paramount importance to obtain greater insights into the pathogenesis of the disease. Thus far, neurotoxin-based animal models have been the most popular tools employed to produce selective neuronal death in both in vitro and in vivo systems. These models have been commonly referred to as the pathogenic models. The current trend in modeling PD revolves around what can be called the disease gene-based models or etiologic models. The value of utilizing multiple models with a different mechanism of insult rests on the premise that dopamine-producing neurons die by stereotyped cascades that can be activated by a range of insults, from neurotoxins to downregulation and overexpression of disease-related genes. In this position article, we present the relevance of both pathogenic and etiologic models as well as the concept of clinically relevant designs that, we argue, should be utilized in the preclinical development phase of new neuroprotective therapies before embarking into clinical trials. (C) 2012 Movement Disorder Society

Publiceringsår

2013

Språk

Engelska

Sidor

61-70

Publikation/Tidskrift/Serie

Movement Disorders

Volym

28

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Neurology

Nyckelord

  • 6-OHDA
  • MPTP
  • alpha-synuclein
  • LRRK2
  • neurodegeneration
  • dopamine
  • viral
  • vectors

Status

Published

Forskningsgrupp

  • Brain Repair and Imaging in Neural Systems (BRAINS)

ISBN/ISSN/Övrigt

  • ISSN: 0885-3185