Topical dsRNA challenges may induce overexpression of airway antiviral cytokines in symptomatic allergic disease. A pilot in vivo study in nasal airways.
Författare
Summary, in English
Airway challenge with dsRNA is of interest since this agent acts on TLR3 and mimics rhinoviral (RV) infection-induced interferons/cytokines. Contrasting frequent employment of dsRNA in epithelial cell cultures there is no information on effects of dsRNA administered to human airways in vivo. Here we explore effects of nasal dsRNA challenges in subjects with seasonal allergic rhinitis inside and outside Swedish birch pollen season.
Publiceringsår
2014
Språk
Engelska
Sidor
1816-1819
Publikation/Tidskrift/Serie
Respiratory Medicine
Volym
108
Issue
12
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Respiratory Medicine and Allergy
Status
Published
Forskningsgrupp
- Respiratory Immunopharmacology
ISBN/ISSN/Övrigt
- ISSN: 1532-3064