Boronate-containing polymers form affinity complexes with mucin and enable tight and reversible occlusion of mucosal lumen by poly (vinyl alcohol) gel

Summary, in English

Copolymers of N-acryloyl-m-aminophenylboronic acid (NAAPBA) with N,N-dimethylarcrylamide (DMAA) formed insoluble interpolymer complexes with mucin from porcine stomach at pH 9.0. The complex formation based on boronate-sugar interactions took place between the similarly charged macromolecules and resulted in coacervate particles formation, which depended both on pH and ionic strength of the solution. the coacervation rate displayed a maximum at the intermediate DMAA_NAAPBA copolymer: mucin weight ratio, that is a pattern typical of interpolymer complex formation.

• Författare: Alexander Ivanov; Lars Nilsson; Igor Galaev; Bo Mattiasson
• Avdelning/ar: Bioteknik; Department of Food Technology, Engineering and Nutrition
• Publiceringsår: 2008
• Språk: Engelska
• Sidor: 36-43
• Publikation/Tidskrift/Serie: International Journal of Pharmaceutics
• Volym: 358
• Issue: 1-2
• Länkar: http://dx.doi.org/10.1016/j.ijpharm.2008.02.017
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Industrial Biotechnology; Food Engineering
• Nyckelord: Mucoadhesive; Drug delivery; Boronic acid; Controlled release; Smart material
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1873-3476