Heme A biosynthesis
Författare
Summary, in English
Respiration in plants, most animals and many aerobic microbes is dependent on heme A. This is a highly specialized type of heme found as prosthetic group in cytochrome a-containing respiratory oxidases. Heme A differs structurally from heme B (protoheme IX) by the presence of a hydroxyethylfarnesyl group instead of a vinyl side group at the C2 position and a formyl group instead of a methyl side group at position C8 of the porphyrin macrocycle. Heme A synthase catalyzes the formation of the formyl side group and is a poorly understood heme-containing membrane bound atypical monooxygenase. This review presents our current understanding of heme A synthesis at the molecular level in mitochondria and aerobic bacteria. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes. (C) 2012 Elsevier B.V. All rights reserved.
Avdelning/ar
Publiceringsår
2012
Språk
Engelska
Sidor
920-927
Publikation/Tidskrift/Serie
Biochimica et Biophysica Acta - Bioenergetics
Volym
1817
Issue
6
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Microbiology
Nyckelord
- Cytochrome biogenesis
- Heme synthesis
- CtaA
- COX15
- Oxidase assembly
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0005-2728