Phomol, a new antiinflammatory metabolite from an endophyte of the medicinal plant Erythrina crista-galli
Författare
Summary, in English
Phomol (1), a novel antibiotic, was isolated from fermentations of a Phomopsis species in the course of a screening of endophytic fungi from the medicinal plant Erythrina crista-galli. For this Argentinean leguminosa anti inflammatory and neuroleptic activities have been described. The compound exhibits antifungal, antibacterial and weak cytotoxic acticity. The anti inflammatory activity was tested in different reporter gene assays (TNF-alpha, STAT1/STAT2 and NF-kappaB) and in an ear edema model in mice. In the reporter gene assays I exhibited no activity, whereas I showed interesting antiinflammatory activity in the mouse ear assay. The compound is a polyketide lactone and its structure was elucidated by spectroscopic methods.
Avdelning/ar
Publiceringsår
2004
Språk
Engelska
Sidor
559-563
Publikation/Tidskrift/Serie
Journal of Antibiotics
Volym
57
Issue
9
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Japan Antibiotics Research Association
Ämne
- Organic Chemistry
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0021-8820