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Enzymatic synthesis of dipeptide units of the D-D-configuration in aqueous media

In English

Författare

Summary, in English

The enzymatic synthesis of dipeptide units of the d-d-configuration in aqueous media, catalysed by muramoyl-pentapeptide carboxypeptidase (E.C.3.4.17.8), is described. Ac-l-Lys(Ac)-d-Ala-d-Lac-OH and Ac-d-Ala-OMe were used as acyl-components. Neutral, basic, and hydrophobic amino acids acting as nucleophiles were incorporated. The enzyme is stereospecific in that only the d-enantiomers of amino acids or amino acid derivatives were incorporated. As nucleophiles, the unmodified amino acids resulted in higher product yields compared with using the corresponding amino acid derivatives. Product yields ranged from 40 to 87%

Publiceringsår

1990

Språk

Engelska

Sidor

147-152

Publikation/Tidskrift/Serie

International Journal of Peptide and Protein Research

Volym

35

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Munksgaard Forlag

Ämne

  • Biochemistry and Molecular Biology

Status

Published

Forskningsgrupp

  • Nanomedicine and Biomaterials

ISBN/ISSN/Övrigt

  • ISSN: 0367-8377