Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Markers of high fish intake are associated with decreased risk of a first myocardial infarction

In English

Författare

  • C G Hallgren
  • G Hallmans
  • J H Jansson
  • S L Marklund
  • F Huhtasaari
  • A Schutz
  • Ulf Strömberg
  • B Vessby
  • Staffan Skerfving

Summary, in English

High intake of fish has been associated with reduced risk of CHD. The high content of n-3 polyunsaturated fatty acids (PUFA) in fish has been suggested to be a protective factor. In addition, fish is the entirely dominating source of methylmercury for the general population, and the concentration of Hg in erythrocytes (Ery-Hg) is often used as an index of fish consumption. Our aim was to study the relationships between a first-ever myocardial infarction, Ery-Hg, activity of gluthathione peroxidase in erythrocytes (Ery-GSH-Px) and plasma concentration of the n-3 PUFA eicosapentaenoic and docosahexaenoic acids (P-PUFA). In a population-based prospective nested case-control study within Northern Sweden seventy-eight cases of a first-ever myocardial infarction were compared with 156 controls with respect to Ery-Hg, P-PUFA and Ery-GSH-Px. Both Ery-Hg and P-PUFA, but not Ery-GSH-Px, were significantly higher in subjects reporting high fish intake (at least one meal per week) than in those with lower intake. This finding suggests that Ery-Hg and P-PUFA reflect previous long-term fish intake. Low risk of myocardial infarction was associated with high Ery-Hg or high P-PUFA. In a multivariate model the risk of myocardial infarction was further reduced in subjects with both high Ery-Hg and high P-PUFA (odds ratio 0.16, 95 % CI 0.04, 0.65). In conclusion, there is a strong inverse association between the risk of a first myocardial infarction and the biomarkers of fish intake, Ery-Hg and P-PUFA, and this association is independent of traditional risk factors.

Publiceringsår

2001

Språk

Engelska

Sidor

397-404

Publikation/Tidskrift/Serie

British Journal of Nutrition

Volym

86

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Cambridge University Press

Ämne

  • Nutrition and Dietetics

Nyckelord

  • Fish intake
  • Mercury
  • n-3 polyunsaturated fatty acids
  • Myocardial infarction

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1475-2662