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Oxytocin receptor mimetics prepared by molecular imprinting.

In English

Författare

Summary, in English

Oxytocin receptor mimetics were prepared by molecular imprinting using Z-oxytocin as the template. Comparative binding studies with reference polymers showed that the imprinted polymers recognized both Z-oxytocin and unprotected oxytocin selectively. The dissociation constants were 47 µM and 102 µM,respectively, and the density of binding sites was 12 µmol/g. The synthetic oxytocin receptors were easily prepared, possessed high mechanical and chemical stability, and were reused without loss of selectivity and capacity after regeneration by extraction.

Publiceringsår

2000

Språk

Engelska

Sidor

27-33

Publikation/Tidskrift/Serie

Letters in Peptide Science

Volym

7

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Organic Chemistry

Status

Published

Forskningsgrupp

  • Nanomedicine and Biomaterials

ISBN/ISSN/Övrigt

  • ISSN: 0929-5666