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Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse

In English

Författare

Summary, in English

Brain damaging insults cause alterations in neuronal networks that trigger epileptogenesis, and eventually lead to the appearance of spontaneous seizures. The present experiments were designed to study the cellular expression and functions of a cysteine proteinase inhibitor, cystatin C, whose gene expression is previously shown to be upregulated in the rat hippocampus during status epilepticus (SE)induced epileptogenesis. The present data showed that the expression of cystatin C protein increased in the mouse hippocampus 7 days following SE and localized mainly to astrocytes and microglia. Acute neuronal death in the hippocampus at 24 h after SE was reduced in cystatin C-/- mice. Also, the basal level of neurogenesis in the subgranular layer of dentate gyros was decreased in cystatin C-/- mice compared to wildtype littermates. Interestingly, migration of newly born neurons within the granule cell layer was attenuated in cystatin C-/- mice. These data demonstrate that cystatin C has a role in neuronal death and neurogenesis during SE-induced network reorganization.

Publiceringsår

2005

Språk

Engelska

Sidor

241-253

Publikation/Tidskrift/Serie

Neurobiology of Disease

Volym

20

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Neurosciences

Nyckelord

  • neural stem cells
  • mice
  • knock-out
  • kainic acid
  • hippocampus
  • FGF-2
  • epileptogenesis
  • epilepsy
  • neurodegeneration
  • seizure

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0969-9961