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No association between inhaled corticosteroids and whole body DXA in postmenopausal women.

In English

Författare

Summary, in English

Purpose Postmenopausal women treated with corticosteroids are regarded as a high-risk group due to the effect of both natural bone loss and possible adverse effects of treatment with inhaled corticosteroids (IC). Objective To compare bone mineral density (BMD) in postmenopausal women exposed only to IC (IC group, n = 106) with that of BMD in women not exposed to corticosteroids (n = 124) and women exposed to oral and/or intra-articular injections in addition to inhaled corticosteroids (OC group, n = 3 1). The women were recruited from a population-based prospective cohort study. Methods Dual X-ray absorptiometry (DXA) technique was used to measure BMD in whole body, spine, pelvis and lower extremities. A health questionnaire and an interview about past and present medication use were used. Results The mean duration and dose of IC were 9.5 +/- 4.5 years and 615 mu g daily. Whole body BMD did not significantly differ between the IC group (1.103 g/cm(2)) and the unexposed group (1.087 g/cm(2)). Within the IC group, BMD stratified for cumulative dose of IC, duration or current dose above or below 800 jig did not differ. Z-score BMD for tertiles did not differ when comparing the IC and OC groups. Conclusion No difference in BMD was noted between postmenopausal women exposed to inhaled corticosteroids and unexposed controls nor was there any dose response relationship between inhaled corticosteroid therapy and BMD. Copyright (c) 2006 John Wiley & Sons, Ltd.

Publiceringsår

2006

Språk

Engelska

Sidor

527-535

Publikation/Tidskrift/Serie

Pharmacoepidemiology and Drug Safety

Volym

15

Issue

May 22

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Orthopedics
  • Gerontology, specializing in Medical and Health Sciences
  • Respiratory Medicine and Allergy

Nyckelord

  • bone mineral density
  • cohort study
  • postmenopausal
  • inhaled corticosteroids

Status

Published

Forskningsgrupp

  • Geriatric Medicine
  • Orthopedics - Clinical and Molecular Osteoporosis Research

ISBN/ISSN/Övrigt

  • ISSN: 1053-8569