C4b-binding protein (C4BP) activates B cells through the CD40 receptor

Summary, in English

We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.

• Författare: SR Brodeur; F Angelini; LB Bacharier; Anna Blom; E Mizoguchi; H Fujiwara; A Plebani; LD Notarangelo; Björn Dahlbäck; E Tsitsikov; RS Geha
• Avdelning/ar: Institutionen för translationell medicin; Klinisk kemi, Malmö
• Publiceringsår: 2003
• Språk: Engelska
• Sidor: 837-848
• Publikation/Tidskrift/Serie: Immunity
• Volym: 18
• Issue: 6
• Länkar: http://www.immunity.com/content/article/abstract?uid=PIIS1074761303001493
• Dokumenttyp: Artikel i tidskrift
• Förlag: Cell Press
• Ämne: Immunology in the medical area
• Status: Published
• Forskningsgrupp: Clinical Chemistry, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1074-7613