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PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells

In English

Författare

  • Lena Eliasson
  • Erik Renström
  • Carina Ammala
  • Per-Olof Berggren
  • Alejandro M. Bertorello
  • Krister Bokvist
  • Alexander Chibalin
  • Jude T. Deeney
  • Peter R. Flatt
  • Jakob Gabel
  • Jesper Gromada
  • Olof Larsson
  • Per Lindstrom
  • Christopher J. Rhodes
  • Patrik Rorsman
Visa allt

Summary, in English

Hypoglycemic sulfonylureas represent a group of clinically useful antidiabetic compounds that stimulate insulin secretion from pancreatic beta cells. The molecular mechanisms involved are not fully understood but are believed to involve inhibition of potassium channels sensitive to adenosine triphosphate (KATP channels) in the beta cell membrane, causing membrane depolarization, calcium influx, and activation of the secretory machinery. In addition to these effects, sulfonylureas also promoted exocytosis by direct interaction with the secretory machinery not involving closure of the plasma membrane KATP channels. This effect was dependent on protein kinase C (PKC) and was observed at therapeutic concentrations of sulfonylureas, which suggests that it contributes to their hypoglycemic action in diabetics.

Publiceringsår

1996

Språk

Engelska

Sidor

813-815

Publikation/Tidskrift/Serie

Science

Volym

271

Issue

5250

Dokumenttyp

Artikel i tidskrift

Förlag

American Association for the Advancement of Science (AAAS)

Ämne

  • Endocrinology and Diabetes

Status

Published

Forskningsgrupp

  • Diabetes - Islet Patophysiology

ISBN/ISSN/Övrigt

  • ISSN: 1095-9203