Surveillance of Vaccine Safety: Comparison of parental reports with routine surveillance and a clinical trial

Summary, in English

One way to maintain confidence in vaccination programmes is to improve monitoring of immunisation safety. We studied active parental reporting of adverse events after a booster dose of diphtheria-tetanus toxoid (DT). 7193 children received the vaccine. Questionnaires were submitted by 84.2% of the parents, who reported reactions for 9.2% of the children. Four percent of events were classified as moderate/severe by interviews. Relative risk of redness and swelling reported was 0.24 (95% CI. 0.13-0.42) compared to a clinical trial, while it was 71.0 (44-114) compared to passive surveillance. Active surveillance by parental reports is a useful complement to passive surveillance of childhood immunisations to generate hypotheses for evaluation in controlled studies. (C) 2009 Elsevier Ltd. All rights reserved.

• Författare: Eva Netterlid; Marie Edwinson Månsson; Anders Håkansson
• Avdelning/ar: Allmänmedicin och samhällsmedicin; Institutionen för hälsovetenskaper
• Publiceringsår: 2009
• Språk: Engelska
• Sidor: 2042-2047
• Publikation/Tidskrift/Serie: Vaccine
• Volym: 27
• Issue: 14
• Länkar: http://dx.doi.org/10.1016/j.vaccine.2009.01.131
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Nursing; Public Health, Global Health, Social Medicine and Epidemiology
• Nyckelord: Local reactions; Vaccine safety; Parental reports
• Status: Published
• Forskningsgrupp: Family Medicine and Community Medicine
• ISBN/ISSN/Övrigt: ISSN: 1873-2518