Nanowires and Neural interfaces. Biocompatibility in the brain
Författare
Summary, in English
A neural interface with a nanostructured surface needs to be protected from damage during the implantation procedure. In paper III, we showed that embedding the nanowire substrate in a temporary protective and stiffening matrix, consisting of gelatin and glycerol, preserved the majority of the nanowires during implantation into agar.
In paper IV, we showed that implanting multiple wire bundles in the brain does not result in an increased glial response to each individual implant. This implies that it is feasible to interface and interact with several brain structures in parallel without the confounding factor of an over all cumulatively increased glial response.
In summary, this thesis has provided key knowledge about how to design and implant a nanowire structured neural interface. The development of a seamlessly integrating neural interface would have immense implications in neuroscience research as well as in clinical settings.
Publiceringsår
2016
Språk
Engelska
Publikation/Tidskrift/Serie
Doctoral dissertation series / Lund University, Faculty of Medicine.
Fulltext
- Available as PDF - 67 MB
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Dokumenttyp
Doktorsavhandling
Förlag
Lund University: Faculty of Medicine
Ämne
- Medical and Health Sciences
Nyckelord
- neural interface
- neurons
- BMI
- nanowires
- tissue responses
- rat
- biocompatibility
- astrocytes
- microglia
Status
Published
Forskningsgrupp
- Neuronano Research Center (NRC)
ISBN/ISSN/Övrigt
- ISSN: 1652-8220
- ISBN: 978-91-7619-319-8
Försvarsdatum
30 september 2016
Försvarstid
13:00
Försvarsplats
Segerfalksalen, BMC A10, Sölvegatan 17, Lund.
Opponent
- Andrew Jackson (Dr)