Angiotensin II-induced vasodilatation in cerebral arteries is mediated by endothelium-derived hyperpolarising factor.
Författare
Summary, in English
The angiotensin II-induced vasodilatation was evaluated in rat middle cerebral artery, especially regarding endothelium-derived hyperpolarising factor (EDHF), by use of a pressurised arteriograph. The angiotensin II dilatation was partly antagonised by inhibitors of nitric oxide synthase and cyclo-oxygenase. The remaining dilatation was inhibited by the potassium channel blockers, charybdotoxin and apamin, providing direct evidence that angiotensin II induces EDHF-mediated dilatation in cerebral arteries. The angiotensin II dilatation was blocked by the angiotensin AT(1) and AT(2) receptor blockers candesartan and PD 123319. Both angiotensin AT(1) and AT(2) receptors were detected on the endothelium by imnitmohistochemistry. (c) 2005 Elsevier B.V. All rights reserved.
Avdelning/ar
Publiceringsår
2006
Språk
Engelska
Sidor
259-263
Publikation/Tidskrift/Serie
European Journal of Pharmacology
Volym
531
Issue
1-3
Fulltext
- Available as PDF - 134 kB
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Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Pharmacology and Toxicology
Nyckelord
- cerebral artery
- hyperpolarising factor
- angiotensin II
- endothelium-derived
- vasodilatation
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1879-0712