Building authentic midbrain dopaminergic neurons from stem cells - lessons from development
Författare
Summary, in English
The challenge with controlling the differentiation of human pluripotent cells to generate functional dopaminergic neurons for the treatment of Parkinson's disease has undergone significant progress in recent years. Here, we summarize the differences between newer and older protocols for generating midbrain dopaminergic neurons from human pluripotent stem cells, and we highlight the importance of following developmental pathways during differentiation. The field has now developed to a point where it is timely to take human pluripotent stem cells one step closer to clinical use, and cell criteria to be fulfilled for such developments are outlined in this review.
Avdelning/ar
Publiceringsår
2012
Språk
Engelska
Sidor
314-319
Publikation/Tidskrift/Serie
Translational Neuroscience
Volym
3
Issue
4
Dokumenttyp
Artikel i tidskrift
Förlag
Versita
Ämne
- Neurology
Nyckelord
- Stem cells
- Dopaminergic neurons
- Differentiation
- Development
Status
Published
Forskningsgrupp
- Developmental and Regenerative Neurobiology
ISBN/ISSN/Övrigt
- ISSN: 2081-6936