Size-dependent long-term tissue response to biostable nanowires in the brain.
Författare
Summary, in English
Nanostructured neural interfaces, comprising nanotubes or nanowires, have the potential to overcome the present hurdles of achieving stable communication with neuronal networks for long periods of time. This would have a strong impact on brain research. However, little information is available on the brain response to implanted high-aspect-ratio nanoparticles, which share morphological similarities with asbestos fibres. Here, we investigated the glial response and neuronal loss in the rat brain after implantation of biostable and structurally controlled nanowires of different lengths for a period up to one year post-surgery. Our results show that, as for lung and abdominal tissue, the brain is subject to a sustained, local inflammation when biostable and high-aspect-ratio nanoparticles of 5 μm or longer are present in the brain tissue. In addition, a significant loss of neurons was observed adjacent to the 10 μm nanowires after one year. Notably, the inflammatory response was restricted to a narrow zone around the nanowires and did not escalate between 12 weeks and one year. Furthermore, 2 μm nanowires did not cause significant inflammatory response nor significant loss of neurons nearby. The present results provide key information for the design of future neural implants based on nanomaterials.
Publiceringsår
2015
Språk
Engelska
Sidor
172-183
Publikation/Tidskrift/Serie
Biomaterials
Volym
42
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Bioengineering Equipment
Status
Published
Projekt
- Vävnadsreaktioner i nervsystemet efter elektrodimplantation
Forskningsgrupp
- Neuronano Research Center (NRC)
- Neurophysiology
ISBN/ISSN/Övrigt
- ISSN: 1878-5905