Assessment and Treatment of Impaired Insulin- Secretion and Action in Type 2 Diabetes
Författare
Summary, in English
GITT showed good reproducibility and the index of insulin sensitivity derived from the GITT showed good correlation with the M-value from the euglycaemic clamp. The test also showed good discriminating capacity between individuals with varying degrees of glucose tolerance (Paper I). Both pioglitazone and insulin glargine were effective in reducing HbA1c levels in combination with other oral glucose lowering agents but pioglitazone caused fluid retention and increased levels of natriuretic peptides suggesting increased cardiac load (Papers II & IV). While pioglitazone improved insulin sensitivity and lipids, insulin glargine resulted in improved β-cell function (Paper IV). Pioglitazone also caused an increase in eye protrusion in a subgroup of patients, probably by causing an increase in retrobulbar adipogenesis (Paper III). Taken together, these results can hopefully help clinicians in the choice of novel add-on treatment and in monitoring of untoward side effects. GITT seems to be a promising tool for assessing insulin secretion and action in clinical practice.
Avdelning/ar
Publiceringsår
2008
Språk
Engelska
Publikation/Tidskrift/Serie
Lund University Faculty of Medicine Doctoral Dissertation Series
Volym
2008:49
Fulltext
- Available as PDF - 752 kB
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Dokumenttyp
Doktorsavhandling
Förlag
Department of Clinical Sciences, Lund University
Ämne
- Endocrinology and Diabetes
Nyckelord
- Type 2 diabetes
- insulin secretion
- glucagon test
- insulin resistance
- insulin glargine
- insulin tolerance test
- thiazolidinediones
- natriuretic peptides
- adiponectin
- thyroid associated ophthalmopathy
- proinsulin
Status
Published
Forskningsgrupp
- Genomics, Diabetes and Endocrinology
Handledare
- Leif Groop
- Anders Frid
ISBN/ISSN/Övrigt
- ISSN: 1652-8220
- ISBN: 978-91-86059-02-6
Försvarsdatum
9 maj 2008
Försvarstid
09:00
Försvarsplats
Stora Aulan, Medicinsk Forskningscentrum, Ingång 59, Universitetssjukhuset MAS, Malmö
Opponent
- Christian Berne (Professor)