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Use of moist oral snuff (snus) and pancreatic cancer : Pooled analysis of nine prospective observational studies

In English

Författare

  • Marzieh Araghi
  • Maria Rosaria Galanti
  • Michael Lundberg
  • Anton Lager
  • Gunnar Engström
  • Lars Alfredsson
  • Anders Knutsson
  • Margareta Norberg
  • Malin Sund
  • Patrik Wennberg
  • Ylva Trolle Lagerros
  • Rino Bellocco
  • Nancy L. Pedersen
  • Per Olof Östergren
  • Cecilia Magnusson
Visa allt

Summary, in English

While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco is less well understood. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between Swedish snus use and the risk of pancreatic cancer. A total of 424,152 male participants from nine cohort studies were followed up for risk of pancreatic cancer through linkage to health registers. We used shared frailty models with random effects at the study level, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for confounding factors. During 9,276,054 person-years of observation, 1,447 men developed pancreatic cancer. Compared to never-snus use, current snus use was not associated with risk of pancreatic cancer (HR 0.96, 95% CI 0.83-1.11) after adjustment for smoking. Swedish snus use does not appear to be implicated in the development of pancreatic cancer in men. Tobacco smoke constituents other than nicotine or its metabolites may account for the relationship between smoking and pancreatic cancer.

Publiceringsår

2017-05-19

Språk

Engelska

Sidor

687-693

Publikation/Tidskrift/Serie

International Journal of Cancer

Volym

141

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Cancer and Oncology

Nyckelord

  • Incidence
  • Pancreatic cancer
  • Snus

Aktiv

Published

Forskningsgrupp

  • Cardiovascular Research - Epidemiology
  • Social Medicine and Global Health

ISBN/ISSN/Övrigt

  • ISSN: 0020-7136