Knee injuries and their consequences – the impact of impact
Författare
Summary, in English
In this work it was found that subjects with post-traumatic OA secondary to an ACL injury have more joint space narrowing and more osteophytes in the lateral compartment than in the medial compartment, compared with subjects with non-traumatic OA. Furthermore, it was found that an acute knee injury is associated with instant and sustained synovial fluid biochemical alterations within the first month of knee injury, suggestive of increased cartilage turnover and severe joint inflammation. Those subjects who sustained an osteochondral fracture with disrupted cortical bone in association with the soft tissue knee injury had increased joint inflammation. In an in vitro bovine cartilage study, mechanical injury to cartilage increased the matrix metalloproteinase-induced cleavage of cartilage aggrecan. Moreover, findings from this model suggest that the aggrecan degradation may differ between cytokine-stimulated cartilage explants compared with cartilage explants mechanically injured and (or) co-incubated with joint capsule.
Conclusively, the findings in this work underline the fact that the initial impact associated with an ACL appears to be important in terms of the risk of developing post-traumatic OA. In addition, this work emphasizes how the acute biological response to injury could be involved in cartilage degradation. A greater understanding of these processes could lead to the improved management of knee-injured patients and possibly delay, or even prevent, OA development.
Avdelning/ar
Publiceringsår
2014
Språk
Engelska
Publikation/Tidskrift/Serie
Lund University Faculty of Medicine Doctoral Dissertation Series
Volym
2014:60
Fulltext
Dokumenttyp
Doktorsavhandling
Förlag
Department of Orthopaedics, Lund University
Ämne
- Orthopedics
Status
Published
Handledare
- Harald Roos
- Martin Englund
- Richard Frobell
- André Struglics
ISBN/ISSN/Övrigt
- ISSN: 1652-8220
- ISBN: 978-91-87651-86-1
Försvarsdatum
23 maj 2014
Försvarstid
13:00
Försvarsplats
Segerfalksalen, Sölvegatan 17, BMC, Lund
Opponent
- Lars Engebretsen