Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.
Författare
Summary, in English
Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. Less is known about effects of hypoxia on non-malignant cells. Here we address whether hypoxia influences the differentiation stage of non-malignant breast epithelial cells and potentially have bearing on early stages of tumorigenesis.
Avdelning/ar
- Institutionen för translationell medicin
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publiceringsår
2012
Språk
Engelska
Publikation/Tidskrift/Serie
PLoS ONE
Volym
7
Issue
9
Fulltext
- Available as PDF - 921 kB
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Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Public Library of Science (PLoS)
Ämne
- Cancer and Oncology
Nyckelord
- hypoxia
- Breast cancer
- differentiation
- epithelial cells
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1932-6203