Limitations of chromosome classification by multicolor karyotyping
Författare
Summary, in English
Multicolor karyotyping technologies, such as spectral karyotyping (SKY) (Schrock et al.1996; Liyanage et al. 1996) and multiplex (M-) FISH (Speicher et al. 1996), have proved to be extremely useful in prenatal, postnatal, and cancer cytogenetics. However, these technologies have inherent limitations that, in certain situations, may result in chromosomal misclassification. In this report, we present nine cases, which fall into five categories, in which multicolor karyotyping has produced erroneous interpretations. Most errors appear to have a similar mechanistic basis.
Avdelning/ar
Publiceringsår
2001
Språk
Engelska
Sidor
1043-1047
Publikation/Tidskrift/Serie
American Journal of Human Genetics
Volym
68
Issue
4
Dokumenttyp
Artikel i tidskrift
Förlag
Cell Press
Ämne
- Medical Genetics
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0002-9297