miRNA in mycosis fungoides and skin inflammation.

Summary, in English

In this mini-review, progress in our understanding of the link between miRNAs and cytokines in inflammatory skin diseases is highlighted with focus on miR-155 in mycosis fungoides (MF). MF is the most common variant of cutaneous T-cell lymphoma (CTCL) and is characterized by malignant T-cell proliferation in a chronic inflammatory environment in affected skin. Recent data show that miR-155 is expressed in situ by both malignant and non-malignant T cells, induced via the STAT5 signal pathway and IL-2Rbeta/gamma cytokines, and thus suggest the importance of miR-155 in malignant proliferation, clinical diagnosis, and prognosis in CTCL.

• Författare: Jenny L Persson
• Avdelning/ar: Experimentell cancerforskning, Malmö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publiceringsår: 2013
• Språk: Engelska
• Sidor: 1017-1019
• Publikation/Tidskrift/Serie: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
• Volym: 121
• Issue: 11
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/24106870?dopt=Abstract; http://dx.doi.org/10.1111/apm.12186
• Dokumenttyp: Artikel i tidskrift
• Förlag: John Wiley & Sons Inc.
• Ämne: Cancer and Oncology
• Status: Published
• Forskningsgrupp: Experimental Cancer Research, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1600-0463