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Temperature limited fed-batch cultivation with a probing feeding strategy for Escherichia coli

  • Marie-Noelle Pons
  • Jan Van Impe
Publiceringsår: 2004
Språk: Engelska
Sidor: 73-79
Publikation/Tidskrift/Serie: Computer Applications in Biotechnology 2004
Dokumenttyp: Konferensbidrag
Förlag: International Federation of Automatic Control


A cultivation strategy combining the advantages of temperature limitedfed-batch and probing control is presented.This is a suitable way to produce recombinant proteins while minimizing therelease of endotoxins which complicates the downstream processing.The downside with the temperature limited fed-batch technique has been the difficulty to achieve a controlled excess of glucose inthe reactor without the accumulation of acetic acid when usingstandard sensors.A method using a probing feeding strategy withdown-pulses is here suggested. The technique is investigated insimulations and experiments.


  • Control Engineering
  • Industrial Biotechnology
  • temperature control
  • Escherichia coli
  • Fermentation process
  • feeding strategy


  • ISBN: 0-08-044251-X

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