Deoxyribonucleoside kinases: two enzyme families catalyze the same reaction
Författare
Summary, in English
Mammals have four deoxyribonucleoside kinases, the cytoplasmic (TK1) and mitochondrial (TK2) thymidine kinases, and the deoxycytidine (dCK) and deoxyguanosine (dGK) kinases, which salvage the precursors for nucleic acids synthesis. In addition to the native deoxyribonucleoside substrates, the kinases can phosphorylate and thereby activate a variety of anti-cancer and antiviral prodrugs. Recently, the crystal structure of human TK1 has been solved and has revealed that enzymes with fundamentally different origins and folds catalyze similar, crucial cellular reactions.
Avdelning/ar
Publiceringsår
2005
Språk
Engelska
Sidor
225-228
Publikation/Tidskrift/Serie
Trends in Biochemical Sciences
Volym
30
Issue
5
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Biological Sciences
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0167-7640