Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Early Cellular Pathways of Mouse Natural Killer Cell Development.

In English

Författare

Summary, in English

Natural killer (NK) cells are large granular lymphocytes that are components of the innate immune system. These cells are key players in the defense against viral and other microbial infections and cancer and have an important function during pregnancy, autoimmunity and allergy. Furthermore, NK cells play important roles in hematopoietic stem cell (HSC) transplantation by providing the graft versus leukemia effect and preventing the development of graft versus host disease. Thus, understanding the developmental pathway(s) from multipotent HSCs to the NK cell lineage-restricted progenitors is of significant clinical value. However, despite extensive progress in the delineation of mature blood cell development, including the B- and T-cell lineages, the early stages of NK cell lineage commitment and development have been less well established and characterized. Here, I review the progress made thus far in dissecting the developmental stages, from HSCs in the bone marrow to the lineage-committed NK cells in mouse.

Publiceringsår

2011

Språk

Engelska

Sidor

329-336

Publikation/Tidskrift/Serie

Journal of Innate Immunity

Volym

3

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Karger

Ämne

  • Immunology in the medical area

Status

Published

Forskningsgrupp

  • Lymphoid Development and Regulation

ISBN/ISSN/Övrigt

  • ISSN: 1662-811X