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IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively

In English

Författare

  • Dorine Sichien
  • Charlotte L. Scott
  • Liesbet Martens
  • Matthias Vanderkerken
  • Sofie Van Gassen
  • Maud Plantinga
  • Thorsten Joeris
  • Sofie De Prijck
  • Leen Vanhoutte
  • Manon Vanheerswynghels
  • Gert Van Isterdael
  • Wendy Toussaint
  • Filipe Branco Madeira
  • Karl Vergote
  • William W. Agace
  • Björn E. Clausen
  • Hamida Hammad
  • Marc Dalod
  • Yvan Saeys
  • Bart N. Lambrecht
  • Martin Guilliams
Visa allt

Summary, in English

Interferon regulatory factor-8 (IRF8) has been proposed to be essential for development of monocytes, plasmacytoid dendritic cells (pDCs) and type 1 conventional dendritic cells (cDC1s) and remains highly expressed in differentiated DCs. Transcription factors that are required to maintain the identity of terminally differentiated cells are designated “terminal selectors.” Using BM chimeras, conditional Irf8fl/fl mice and various promotors to target Cre recombinase to different stages of monocyte and DC development, we have identified IRF8 as a terminal selector of the cDC1 lineage controlling survival. In monocytes, IRF8 was necessary during early but not late development. Complete or late deletion of IRF8 had no effect on pDC development or survival but altered their phenotype and gene-expression profile leading to increased T cell stimulatory function but decreased type 1 interferon production. Thus, IRF8 differentially controls the survival and function of terminally differentiated monocytes, cDC1s, and pDCs.

Publiceringsår

2016-09-20

Språk

Engelska

Sidor

626-640

Publikation/Tidskrift/Serie

Immunity

Volym

45

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Cell Press

Ämne

  • Immunology in the medical area

Nyckelord

  • dendritic cell
  • development
  • IRF4
  • IRF8
  • lineage
  • monocyte
  • plasmacytoid dendritic cell
  • terminal selector
  • transcription factor

Status

Published

Forskningsgrupp

  • Mucosal Immunology

ISBN/ISSN/Övrigt

  • ISSN: 1074-7613