Synthesis of naphthoxylosides on solid support
Författare
Summary, in English
In order to investigate the selective antiproliferative effects shown by 2-(6-hydroxynaphthyl)-beta-D-xylopyranoside the 14 possible beta-D-xylopyranosidic compounds were synthesized on solid support. An aminomethylated polystyrene resin was converted into an acid chloride resin and then esterified using dihydroxynaphthalene. The free hydroxy group was then xylosylated Under BF3.OEt2 mediated conditions. The xyloside was deprotected and simultaneously cleaved off the resin Using NaOMe/MeOH. Final purification using reverse phase HPLC gave the pure xylosides in 6-42% yield with Virtually no formation of alpha-xylosides. (C) 2002 Elsevier Science Ltd. All rights reserved.
Avdelning/ar
Publiceringsår
2002
Språk
Engelska
Sidor
6549-6552
Publikation/Tidskrift/Serie
Tetrahedron Letters
Volym
43
Issue
37
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Chemical Sciences
Nyckelord
- solid support
- antiproliferative
- xylosides
- dihydroxynaphthalenes
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0040-4039