Combinations of cereal β-glucans and probiotics can enhance the anti-inflammatory activity on host cells by a synergistic effect
Författare
Summary, in English
The influence of oat and barley β-glucans on some features of diverse probiotic strains was investigated. Neither barley nor oat β-glucans supported the growth of any of the investigated strains when used as the sole carbon source in fermentation media. No protective effect by β-glucans was observed on bacterial survival to in vitro simulation of the human digestive tract. Moreover, the presence of β-glucans did not enhance the ability of probiotic bacteria to adhere on human intestinal cells. The immunomodulatory activities of probiotics, β-glucans, and their combinations were studied and compared in vitro by transcriptional analysis of immune-related genes on LPS-stimulated THP-1 macrophages. Immune modulating properties were evidenced. In particular, mixtures of probiotic microorganisms and barley β-glucans exhibited synergistic effects in modulating the transcriptional level of several immune-related genes, leading to an overall enhanced anti-inflammatory effect. Together, these findings suggest a promising application of probiotic bacteria and β-glucans in the preparation of dietary mixtures presenting health-promoting features such as immunomodulatory properties.
Avdelning/ar
- Food for Health Science Centre
Publiceringsår
2016-05-01
Språk
Engelska
Sidor
12-23
Publikation/Tidskrift/Serie
Journal of Functional Foods
Volym
23
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Food Science
- Nutrition and Dietetics
Nyckelord
- Beta Glucan (PubChem CID: 9202437)
- Immune system
- Prebiotics
- Probiotics
- Relative gene expression
- Synbiotics
- β-glucan
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1756-4646