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Fatty-acid-displaced transcriptional repressor, a conserved regulator of cytochrome P450 102 transcription in Bacillus species

Publiceringsår: 2001
Språk: Engelska
Sidor: 459-464
Publikation/Tidskrift/Serie: Archives of Microbiology
Volym: 176
Nummer: 6
Dokumenttyp: Artikel i tidskrift
Förlag: Springer


Bacillus subtilis strain 168 encodes two flavocytochromes P450, Cyp102A2 and Cyp102A3. The cyp102A3 gene is preceded by, and organized in an operon with, a gene for a transcriptional regulator, encoded by fatR. The paralogous gene, cyp102A2, is most likely transcribed as a mono-cistronic message. We show that fatR encodes a protein that binds to an operator sequence that is present upstream of its own reading frame, thereby repressing the expression of the fatR-cyp102A3 operon. Unsaturated fatty acids and phytanic acid have the capacity to interact with FatR and to abrogate its binding to the operator sequence.


  • Immunology in the medical area
  • Microbiology in the medical area
  • Cyp102A2
  • Cyp102A1
  • FatR
  • Bacillus subtilis
  • cytochrome P450
  • P450BM-3
  • Cyp102A3


  • ISSN: 0302-8933

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