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Cystatin C and cathepsins in cardiovascular disease.

In English

Författare

Summary, in English

Cystatin C and cathepsins could play a role in almost all processes involved in atherosclerotic lesion formation by their degradation of extracellular matrix proteins and apolipoprotein B100, the protein moiety of LDL. Several cysteine cathepsins are upregulated in human lesions accompanied by a decrease in cystatin C, the major inhibitor of cysteine cathepsins. Recent research show that atherosclerotic mice deficient in cystatin C display increased elastic lamina degradation as well as larger plaque formation. Cathepsin S- and K-deficient atherosclerotic mice, on the other hand, both have less atherosclerosis, where cathepsin S-/- mice exhibited fewer plaque ruptures and cathepsin K-/- larger foam cells than control mice. This article reviews possible roles of cystatin C and cathepsins in different processes and stages of the atherosclerotic disease.

Publiceringsår

2008

Språk

Engelska

Sidor

5780-5786

Publikation/Tidskrift/Serie

Frontiers in Bioscience

Volym

13

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Frontiers in Bioscience

Ämne

  • Cardiac and Cardiovascular Systems
  • Cell and Molecular Biology

Status

Published

Forskningsgrupp

  • Cardiovascular Research - Immunity and Atherosclerosis

ISBN/ISSN/Övrigt

  • ISSN: 1093-9946